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Panobinostat is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Panobinostat is used in combination with other drugs to treat multiple myeloma. Panobinostat is usually given after other cancer medicines have been tried without success.

Panobinostat was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, the medicine slowed progression of the disease. However, it has not been shown that panobinostat can improve symptoms or lengthen survival time.

Panobinostat may also be used for purposes not listed in this medication guide.

Panobinostat can cause severe diarrhea. Tell your doctor if you have diarrhea with stomach cramps or if you get dehydrated (extreme thirst, decreased urination, sweating or hot and dry skin).

Panobinostat can also cause serious or fatal heart problems. Get emergency medical help if you have chest pain, fast or slow heartbeats, dizziness or fainting, swelling in your legs, or shortness of breath.

While using this medicine, you will need frequent medical tests.

You should not use panobinostat if you are allergic to it.

To make sure panobinostat is safe for you, tell your doctor if you have:

  • heart disease, history of recent heart attack;
  • a personal or family history of Long QT syndrome;
  • liver disease;
  • any type of infection;
  • a bleeding or blood-clotting disorder;
  • if you have been sick with diarrhea; or
  • if you are dehydrated.

Do not use panobinostat if you are pregnant.It could harm the unborn baby. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose. Call your doctor if you think you might be pregnant.

Use birth control to prevent pregnancy,whether you are a man or a woman. Men should use condoms while using panobinostat and for at least 6 months after your last dose.

It is not known whether panobinostat passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Panobinostat is not approved for use by anyone younger than 18 years old.

Farydak Side Effects

Get emergency medical help if you havesigns of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Panobinostat can cause serious or fatal heart problems. Get emergency medical help if you have chest pain, fast or slow heartbeats, dizziness or fainting, swelling in your legs, or shortness of breath.

Call your doctor at once if you have:

  • severe or ongoing vomiting or diarrhea;
  • pink or brown urine;
  • easy bruising or bleeding, bleeding that will not stop;
  • low blood cell counts--fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, rapid heart rate, pale skin, feeling tired or short of breath;
  • signs of an electrolyte imbalance--confusion, headache, slurred speech, increased thirst or urination, leg cramps, constipation, fluttering in your chest, numbness or tingling, muscle weakness, loss of coordination, feeling unsteady;
  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects may include:

  • nausea, vomiting, loss of appetite;
  • diarrhea;
  • fever;
  • swelling in your arms or legs;
  • tired feeling; or
  • low blood cell counts.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Farydak Interactions

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Certain foods may interact with panobinostat and lead to unwanted side effects. Avoid eating star fruit, pomegranate and grapefruit products while taking panobinostat.

This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Other drugs may interact with panobinostat, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Farydak Dosage

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Panobinostat is usually given in combination with other medicines.Follow your doctor's dosing instructions very carefully.

Panobinostat is given in a 21- day treatment cycle, and you may only need to take the medicine during the first 1 to 2 weeks of each cycle. Your doctor will determine how long to treat you with panobinostat.

You may take panobinostat with or without food. Try to take the medicine at the same time on each scheduled day.

Take panobinostat with a full glass of water.

Do not open, crush or chew a panobinostat capsule. Swallow it whole. Do not use a broken capsule.The medicine from a broken capsule can be dangerous if it gets in your eyes, mouth, or nose, or on your skin.If this occurs, wash your skin with soap and water or rinse your eyes with water. Ask your doctor or pharmacist how to safely handle and dispose of a broken capsule.

If you vomit after taking panobinostat, do not take another capsule. Take your next dose as scheduled.

Panobinostat can cause severe diarrhea. You may be given medicine to prevent diarrhea or other side effects while you are receiving panobinostat.

Panobinostat can lower blood cells that help your body fight infections and help your blood to clot.Your blood will need to be tested often.Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG). Your cancer treatments may be delayed based on the results of these tests.

Store the capsules in their original container at room temperature away from moisture, heat, and light.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

If you are less than 12 hours late in taking your medicine, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose.Do nottake extra medicine to make up the missed dose.

Copyright 1996-2019 Cerner Multum, Inc.





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Date: 30.11.2018, 17:56 / Views: 54152